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Initially identified in human plasma, it quickly attracted attention for its unusual ability to accelerate tissue repair and regulate gene expression related to healing and regeneration

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This interpretation is based on the finding that Kras mutations were observed in only 1 in 13 of the lung tumors examined from urethane-treated Nrf2 −/− mice but were observed in 15 of 15 lung tumors obtained from the urethane-treated wild-type mice [182]